Formamidine pesticides octopamine-like actions in a firefly book

Toxicity, interactions, and metabolism of formamidine. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. We report here that the formamidine acaricide insecticide, chlordimeform cdm, and its demethylated deivative can mimic the actions of octopamine at the locust neuromuscular junctions. When these insecticide classes are examined, it becomes clear that the majority of insecticides in use today exert their toxic action on the insect nervous system. Theformamidinepesticide chlordimeform andits ndemethylatedmetabolites cause the light organ ofthefirefly photinus pyralis l. Action of formamidine pesticides on the octopamine. Monodemethyl chlordimeform is active at doses as low as 5 nanograms per insect when applied topically. No general agreement exists concerning their mechanisms of action. Cloning of biogenic amine receptors from moths bombyx mori and.

Pharmacological characterization of a bombyx mori alphaadrenergiclike octopamine receptor stably expressed in a mammalian cell line. Plant essential oils and formamidines as insecticides acaricides. In a number of model systems, including the firefly light organ 4 and the locust extensortibiae muscle 5, the formamidines have been shown to activate octopamine receptors. Synergistic actions of formamidine insecticides on the activity of pyrethroids and neonicotinoids against aedes aegypti diptera. If you need to print pages from this book, we recommend downloading it as a pdf. Actions of sympathomimetic amines on the isolated light organ of the firefly photinus pyralis. It stimulates activity of the firefly light organ nathanson, 1979, induces flight motor activity, and acts as neurotransmittermodulator in the locust central nervous system cns.

This new digital representation of the original work has been recomposed from xml files created from the original paper book, not from the original typesetting files. Ethological and experimental approaches to behavior analysis jstor. Monoamines as targets for insecticide discovery springerlink. Hollingworthoctopaminelike actions of formamidines in the firefly light organ. In view of the current interest in octopamine and its receptors and the demonstration that octopamine receptors are at least one site of action of formamidines, we have examined the action of two formamidines chlordimeform cdm and desmethylchlordimeform dcdm on the octopamine receptors on locust fat body. All the formamidines tested chlordimeform cdm, demethylchlordimeform dcdm, amitraz, and uk 16353 mimicked the action of octopamine by 1 increasing the amplitude and relaxation rate of slow motorneurone tension in the extensortibiae. We report here that the formamidine acaricideinsecticide, chlordimeform cdm, and its demethylated derivative can mimic the actions of octopamine at the locust neuromuscular junction. Alpha2adrenoceptors as a target for formamidine pesticides. The action of two formamidines, chlordimeform cdm and desmethylchlordimeform dcdm, on isolated fat body of locusts has been examined. Chemical strategies for resistance management pesticide. The action of formamidines on octopamine receptors in the locust. This gives the clearest evidence to date of the site of action of the formamidines and indicates a novel mode of action for these pesticides. In a variety of insect species, octopamine has been implicated in both central and peripheral neural functions. Scientific literature fireflyers international network.

Synergistic actions of formamidine insecticides on the activity of. This chapter provides a brief guide to the mode of action of the antiparasitic compounds in current use. Environmental protection agency, and approved for publication. Robert hollingworth michigan state university, mi msu.

The formamidine pesticide chlordimeform and its ndemethylated metabolites cause the light organ of the firefly photinus pyralis l. Table of contents april 04, 1980, 208 4439 science. Plant essential oils and formamidines as insecticidesacaricides. Mode of action of agents used against arthropod parasites. The formamidines are a novel group of acaricideinsecticides, unique both in chemical structure and in their range of biological activities. Abstract the formamidine pesticide chlordimeform and its ndemethylated metabolites cause the light organ of the firefly photinus pyralis l. The results are similar to those from the firefly light organ with phentolamine blocking the action of dcdm, cdm and octopamine. In stimulation experiments its responded to octopamine leading to an inhibition of. Octopaminergic modulation of temporal frequency tuning. The action of formamidines on octopamine receptors in the. Unfortunately, this book cant be printed from the openbook.

The actions of a range of formamidines have been investigated biochemically and physiologically on octopamine receptors in the locust schistocerca gregaria. Formamidine pesticidesactions in insects and acarines. Receptor in hek293 cells and action of a formamidine insecticide. The emphasis reflects more the chemical usage than the extent of the literature. Action of formamidine pesticides on octopamine receptors.